A potentially new relief for urinary problems could be on its way for patients dealing with symptoms of urinary incontinence or overactive bladder as experts reaches improved understanding of how the bladder reacts as it becomes full, according to online news reports.
In a collaborative effort by experts at Beth Israel Deaconess Medical Center and Harvard Medical School, the research team recently found that thin layer of cells which line the surface of the bladder, also known as epithelium, is also able to sense the bladder’s fullness with the help of integrins, a family of transmembrane proteins responsible for the interaction between a cell and the tissues around it. As the bladder approaches its limitation, epithelial cells also stretch and thin out, which in turn, activate integrins to send the message to the nerves and other cells connected to the bladder. This new knowledge, which was reportedly published online in the FASEB journal, may guide researchers in designing drug treatments for bladder problems including urinary incontinence and overactive bladder.
Medications indicated for overactive bladder work in relieving symptoms of incontinence by targeting proteins in the muscles surrounding the bladder wall, causing it to relax, according to the medical journals. Targeting the action of integrins in the bladder’s epithelium could make the discovery of a new urinary incontinence and overactive bladder drug treatment possible, as has been reportedly revealed in the research report.
Overactive bladder and other kinds of urinary incontinence, bladder problems which are relatively more common in women, have been reported to affect millions of people in the United States, according to health experts say. While UI may be treated through nonsurgical options including medications, or behaviorial therapy, women experiencing severe symptoms, especially that of stress urinary incontinence (SUI), may find themselves submitting to mesh surgical procedures for relief. Some mesh devices, however, have been reported to cause serious complications, gathering thousands of bladder mesh lawsuits from a large number of women. The Bladder Mesh Lawsuit Center at bladdermeshlawsuit.us offers comprehensive information pertaining to the adverse effects and other issues related to pelvic mesh devices.
Sources:
medicalnewstoday.com/releases/256151.php
webmd.com/urinary-incontinence-oab/overactive-bladder-treatment-finding-best-options?page=2
mayoclinic.com/health/urinary-incontinence/DS00404/DSECTION=treatments-and-drugs
